Recent Publications
Quarterly Updates: Recent Publications from CF@LANTA and CF-AIR Investigators
1: Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, Burnham
CD, Cuomo CA, Detweiler CS, Forrest GN, Gilbert JA, Lovett S, Maloy S, McAdam A,
Newton I, Reguera G, O'Toole GA, Schloss PD, Shade A, Whiteley M. A call for the
United States to continue investing in science. ASM Case Rep. 2025 Feb
27;1(3):e00043-25. doi: 10.1128/asmcr.00043-25. PMID: 41246371; PMCID:
PMC12530245.
2: Yang BA, Vesga-Castro C, Monteiro da Rocha A, Newton I, Shcherbina A, Wong
SW, Fraczek PM, Larouche JA, Hiraki H, Baker BM, Shin JW, Takayama S, Thouless
MD, Aguilar CA. Manipulation of the nucleoscaffold potentiates cellular
reprogramming kinetics. PNAS Nexus. 2025 Sep 25;4(10):pgaf307. doi:
10.1093/pnasnexus/pgaf307. PMID: 41126997; PMCID: PMC12538391.
3: Barr E, Truitt B, Jergel A, Bai S, McKie K, Sanchez Russo R, Oliver KE,
Linnemann RW. CFTR Variant Frequencies and Newborn Screening Panel
Performance in the Diverse CF Population Receiving Care in the State of Georgia.
Int J Neonatal Screen. 2025 Sep 26;11(4):85. doi: 10.3390/ijns11040085. PMID:
41133697; PMCID: PMC12551088.
4: Truitt B, Barr E, Wittenauer A, Jergel A, Bai S, Sanchez Russo R, Oliver KE,
McKie K, Linnemann RW. Evaluating Georgia's Cystic Fibrosis Newborn Screening
Algorithm to Inform Improvement Recommendations. Int J Neonatal Screen. 2025 Sep
29;11(4):87. doi: 10.3390/ijns11040087. PMID: 41133699; PMCID: PMC12551103.
5: Saglani S, Fitzpatrick AM, Papadopoulos NG, Reznik M, Stokes J. Phenotype-
Based Management of Recurrent Preschool Wheezing and Asthma. J Allergy Clin
Immunol Pract. 2025 Oct;13(10):2563-2571. doi: 10.1016/j.jaip.2025.06.027. Epub
2025 Aug 5. PMID: 40762612.
6: DiFiglia S, Georgiopoulos AM, Seng EK, Portenoy R, Chaudhary N, Yonker LM,
Wang J, Walker P, Stables-Carney T, Middour-Oxler B, Linnemann RW, Kier C,
Friedman D, Berdella MN, Dhingra L. Illness Burden in Adults With Cystic
Fibrosis: Associations With Sex, Race/Ethnicity, and Socioeconomic Risk Factors.
Pediatr Pulmonol. 2025 Oct;60(10):e71306. doi: 10.1002/ppul.71306. PMID:
41090278.
7: Anh Nguyen TT, Zhang J, Iqbal J, Ahmed SS, Liu Y, Yang L, Zhang G, Ning B,
Guo H, Wei S, Hou Y, Agarwal I, Yasmeen S, Khoury T, Ai D, Deng H, Liu Y, Peng
L, Chen YY, Siziopikou KP, Li X. Proposing New Criteria for Classification of
Benign Fibroepithelial Lesions Based on Clinicopathologic Evaluations of 507
Cases with Clinical Outcome. Mod Pathol. 2025 Oct;38(10):100812. doi:
10.1016/j.modpat.2025.100812. Epub 2025 Jun 12. PMID: 40516609.
8: Viola HL, Vasani V, Takayama S. A Protocol Guide to Micro Milling for Bio-
Microfluidics. Bio Protoc. 2025 Oct 5;15(19):e5459. doi:
10.21769/BioProtoc.5459. PMID: 41080440; PMCID: PMC12514131.
9: Kazmerski TM, Stransky OM, Wright CE, Jathal I, Prangley A, Tangpricha V,
Jain R, Barrett SL, Hughan KS, West NE, Taylor-Cousar JL, Sawicki GS. Sexual
health experiences and care utilization of males with cystic fibrosis. J Cyst
Fibros. 2025 Oct 6:S1569-1993(25)02484-1. doi: 10.1016/j.jcf.2025.09.010. Epub
ahead of print. PMID: 41058337.
10: McDonough D, Bezold EL, Wuest WM, Minbiole KPC. The versatile synthesis and
biological evaluation of all-alkyl biscationic quaternary phosphonium compounds:
atom-economical and potent disinfectants. RSC Med Chem. 2025 Oct 8. doi:
10.1039/d5md00660k. Epub ahead of print. PMID: 41122454; PMCID: PMC12536645.
11: Schrader Echeverri E, Kim H, Jang B, Shakked A, Park C, Baek KI, Choi L,
Kang DW, Hung RC, Jeong K, Peck HE, Podilapu AR, Tiegreen KE, Santangelo PJ, Jo
H, Dahlman JE. Microfluidic Device Type Improves Heart mRNA Delivery In
Vivo. Langmuir. 2025 Oct 14;41(40):27123-27132. doi:
10.1021/acs.langmuir.5c02612. Epub 2025 Oct 2. PMID: 41037471; PMCID:
PMC12529952.
12: Goss K, Grant ML, Guglani L, Miller H, Woods EJ, Caldwell C, Fitzpatrick AM,
Horwitz EM. Single cell transcriptional profiling of monocytes from asthma
patients show a predisposition for an inflammatory response. Cytotherapy. 2025
Oct 14:101967. doi: 10.1016/j.jcyt.2025.07.008. Epub ahead of print. PMID:
41263748.
13: Konarkowski J, Astore C, Gibson G. Assessment of genetic and metabolite
associations of branched chain amino acids with metabolic disease in the UK
Biobank using Mendelian randomization. BMC Med Genomics. 2025 Oct 16;18(1):163.
doi: 10.1186/s12920-025-02232-2. PMID: 41102794; PMCID: PMC12532399.
14: Tarquinio KM, Farrell J, Varga JJ, Zhao C, Mehlferber E, Brown SP. Mapping
the respiratory microbiome in intubated children over time. Microbiol Spectr.
2025 Oct 20;13(12):e0044825. doi: 10.1128/spectrum.00448-25. Epub ahead of
print. PMID: 41114498; PMCID: PMC12671211.
15: Goudy L, Ha A, Borah AA, Umhoefer JM, Chow L, Tran C, Winters A, Talbot A,
Hernandez R, Li Z, Subramanya S, Arab A, Kale N, Lee JHJ, Muldoon JJ, Liu C,
Schmidt R, Santangelo P, Carnevale J, Eyquem J, Shy BR, Marson A, Gilbert LA.
Integrated epigenetic and genetic programming of primary human T cells. Nat
Biotechnol. 2025 Oct 21. doi: 10.1038/s41587-025-02856-w. Epub ahead of print.
PMID: 41120666.
16: Asante JYD, Bezold EL, Wuest WM, Minbiole KPC. Triscationic bolaamphiphilic
QACs - optimizing antibacterial therapeutic indices. Bioorg Med Chem Lett. 2026
Feb 1;131:130441. doi: 10.1016/j.bmcl.2025.130441. Epub 2025 Oct 21. PMID:
41130327.
17: Pollard E, Guha A, Harris RA, Wang X, Zhu H, Dong Y, Weintraub NL, Tsai MH.
Cancer history and cardiovascular diseases: Implications for colorectal and
breast cancer screening. J Med Screen. 2025 Oct 22:9691413251388517. doi:
10.1177/09691413251388517. Epub ahead of print. PMID: 41124332.
18: Adewole AH, Chhetri BK, Abdelwahab GM, Bhanushali R, Sweeney-Jones AM,
Greene M, Shim J, Asef CK, Vaelli P, Barrett L, Fernández FM, Quave CL, Kubanek
J. Discovery of Nav1.7 Inhibitors through the Screening of Marine
Natural Product Extracts. J Nat Prod. 2025 Nov 28;88(11):2635-2644. doi:
10.1021/acs.jnatprod.5c00978. Epub 2025 Oct 22. PMID: 41124213; PMCID:
PMC12670511.
19: Yang CA, Batross J, Gonzalez Ramirez LA, Chandler J, Walker D, Tran V, Jones
DP, Olveira G, Ziegler TR, Tangpricha V, Alvarez JA. Assessment of the
metabolome across the glucose tolerance spectrum in adults with cystic fibrosis
hospitalized for pulmonary exacerbations. Respir Med. 2025 Nov-Dec;249:108456.
doi: 10.1016/j.rmed.2025.108456. Epub 2025 Oct 23. PMID: 41135911.
20: Ahmed T, Verma A, Takayama S. Substrate Exclusion Greenlights Physical
Autocatalysis of Enzyme Activity in Membraneless Proto-Organelles.
Biomacromolecules. 2025 Nov 10;26(11):7398-7409. doi:
10.1021/acs.biomac.5c00926. Epub 2025 Oct 29. PMID: 41160155; PMCID:
PMC12606559.
21: Goetgeluck C, Olojo O, Hilton SP, Sablon O 3rd, Freeman L, Person P, Clark
D, Lyles RH, Read TD, Sheikhzadeh C, Wolfe MK, Nadimpalli ML. Using wastewater
surveillance to investigate community-level differences in antibacterial
resistance in a major urban center, USA. Appl Environ Microbiol. 2025 Nov
19;91(11):e0168425. doi: 10.1128/aem.01684-25. Epub 2025 Oct 30. PMID: 41165308;
PMCID: PMC12628767.
22: Briaud P, Tennant JR, Steere RW, Wiemels RE, Whiteley M, Carroll RK.
Analysis of Teg41 and PSMα promoter activity using a divergent fluorescent
reporter plasmid. mSphere. 2025 Nov 25;10(11):e0043225. doi:
10.1128/msphere.00432-25. Epub 2025 Oct 31. PMID: 41170992; PMCID: PMC12645910.
23: Bao L, Zhu Z, Ismail A, Zhu B, Anandan V, Whiteley M, Kitten T, Xu P.
Experimental evolution of gene essentiality in bacteria. mBio. 2025 Oct
31:e0300525. doi: 10.1128/mbio.03005-25. Epub ahead of print. PMID: 41170999.
24: Hicks DJ, Aiosa N, Sinha A, Jaiyesimi OA, Branda SS, Garg N. Metabolomic
profiling of Burkholderia thailandensis infection of airway epithelial
cells provides insights into potential therapeutic targets. mSystems. 2025 Nov
18;10(11):e0061125. doi: 10.1128/msystems.00611-25. Epub 2025 Oct 31. PMID:
41170848; PMCID: PMC12625709.
25: Bruce AS, Suttiratana SC, Grabowski H, Sweeney L, Ward A, Mazuera S, Alvarez
JA, Yablon D, Naranjo D. "All my food is customized*": Barriers & facilitators
concerning nutrition for persons living with cystic fibrosis. J Cyst Fibros.
2025 Nov;24(6):1081-1089. doi: 10.1016/j.jcf.2025.07.012. Epub 2025 Jul 24.
PMID: 40713200.
26: Davis CM, Akin C, Bahna SL, Hsu Blatman KS, Carr T, Chang C, Chong HJ,
Ciaccio CE, Davis BP, Fadugba O, Fuleihan RL, Grayson MH, Gupta S, Hemler JA,
Kumar R, Mahdavinia M, Miller RL, Nelson MR, Nowak-Wegrzyn AH, Poowuttikul P,
Tripple JW, Vickery BP, Zheng T. The state of the academic medical center in
allergy/immunology: Work Group Report of the AAAAI A/I Division Directors
Committee. J Allergy Clin Immunol. 2025 Nov;156(5):1173-1184. doi:
10.1016/j.jaci.2025.05.013. Epub 2025 Jul 31. PMID: 40742349.
27: Kim H, Zenhausern R, Gentry K, Lian L, Huayamares SG, Radmand A, Loughrey D,
Podilapu AR, Hatit MZC, Ni H, Li A, Shajii A, Peck HE, Han K, Hua X, Jia S,
Martinez M, Lee C, Santangelo PJ, Tarantal A, Dahlman JE. Lipid nanoparticle-
mediated mRNA delivery to CD34+ cells in rhesus monkeys. Nat
Biotechnol. 2025 Nov;43(11):1813-1820. doi: 10.1038/s41587-024-02470-2. Epub
2024 Nov 22. PMID: 39578569; PMCID: PMC12095617.
28: Letizia M, Diggle SP, Whiteley M. Pseudomonas aeruginosa: ecology,
evolution, pathogenesis and antimicrobial susceptibility. Nat Rev Microbiol.
2025 Nov;23(11):701-717. doi: 10.1038/s41579-025-01193-8. Epub 2025 May 29.
PMID: 40442328.
29: Gonzalez Ramirez LA, Suppakitjanusant P, Burley TM, Zaveri S, Stecenko AA,
Hunt WR, Harris RA, Stallings VA, Ivie EA, Driggers C, Binongo JN, Ziegler TR,
Alvarez JA. Relationship between skeletal muscle indicators and clinical
outcomes in cystic fibrosis is modified by adiposity and CFTR modulator use: a
cross-sectional analysis. Am J Clin Nutr. 2025 Nov;122(5):1479-1488. doi:
10.1016/j.ajcnut.2025.09.019. Epub 2025 Sep 17. PMID: 40972870.
30: Smirnova N, Gillespie S, Lowers J, Jergel A, Dellon EP, Cammarata-
Mouchtouris A, Fitzpatrick A, Kavalieratos D. Symptom factors and their clinical
correlates among adults with cystic fibrosis. J Cyst Fibros. 2025
Nov;24(6):1124-1129. doi: 10.1016/j.jcf.2025.07.001. Epub 2025 Jul 8. PMID:
40628572; PMCID: PMC12337307.
31: Lee HY, Lee CM, Jarrell ZR, Tran V, Smith MR, Jones DP, Go YM. The effects
of combined low-dose cadmium and deltamethrin on mitochondrial bioenergetics and
metabolism in human lung fibroblasts. Toxicol Rep. 2025 Nov 4;15:102162. doi:
10.1016/j.toxrep.2025.102162. PMID: 41280362; PMCID: PMC12639372.
32: Cui G, Cegla AV, Brown J, Jones K, Reed RC, Tirouvanziam R, Koval M, McCarty
NA. Hyperglycemia differentially affects neutrophil transmigration across cystic
fibrosis and wildtype bronchial epithelia. J Cyst Fibros. 2025 Nov
11:S1569-1993(25)02501-9. doi: 10.1016/j.jcf.2025.11.005. Epub ahead of print.
PMID: 41224544.
33: Chinthrajah RS, Kulis M, Jones SM, Sicherer S, Wang J, Shreffler W, Burk CM,
Kim E, Keet C, Sindher S, Long AJ, Scurlock AM, Lanser BJ, Hui-Beckman JW,
Vickery B, Ezhuthachan ID, Bird JA, Parrish C, Spergel JM, Brown-Whitehorn T,
Dantzer J, Ligueros-Saylan M, Tassinari P, Olsson J, Iqbal A, Ozanne M, Huckabee
C, Rogers N, Yovetich N, Lin A, Brittain E, Wheatley LM, Togias A, Wood RA.
Exploratory Analyses of Predictors and Correlates of Response to Omalizumab
Therapy in Patients with Multiple Food Allergies. J Allergy Clin Immunol. 2025
Nov 12:S0091-6749(25)01124-8. doi: 10.1016/j.jaci.2025.10.031. Epub ahead of
print. PMID: 41238005.
34: Custodio R, Alseth EO, Brockhurst MA, Brown SP, Westra ER. Bacterial immune
systems as causes and consequences of microbiome structure. PLoS Biol. 2025 Nov
19;23(11):e3003489. doi: 10.1371/journal.pbio.3003489. PMID: 41259328; PMCID:
PMC12629431.
35: Florin TA, Reeder R, Ambroggio L, Ruddy RM, Shah SS, Cator A, Lipshaw MJ,
Capraro GA, Sartori LF, Cheng AY, Tzimenatos L, Walsh PS, Morris CR, Rees CA,
McLaren SH, Lubell TR, Larsen CD, Moher J, Klein EJ, Hooli S, Kuppermann N;
Pediatric Emergency Care Applied Research Network (PECARN) PedCAPS
Investigators. Derivation and validation of the Pediatric Community-Acquired
Pneumonia Severity (PedCAPS) score: A prospective cohort study. J Hosp Med. 2025
Nov 21. doi: 10.1002/jhm.70220. Epub ahead of print. PMID: 41272952.
36: Mattingly CLR, Jimenez AR, Williams ME, Kost KN, Lawrence LA, Chen TD,
Michalets SE, Lobby JL, Soto-Vázquez Y, Moore KM, Hicks SL, Danzy S, Elliott JL,
Scharer CD, Swaims-Kohlmeier A, Lowen AC, Mehta A, Kohlmeier JE. Human lung
CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates
subset-specific antiviral programming in airway epithelial cells. Immunity. 2025
Nov 26:S1074-7613(25)00505-9. doi: 10.1016/j.immuni.2025.11.003. Epub ahead of
print. PMID: 41308652.
37: LaRock DL, Sherman JD, Qu C, Ngai W, Read TD, McGavin MJ, LaRock CN.
Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis. Nat
Commun. 2025 Nov 26;16(1):10570. doi: 10.1038/s41467-025-65674-3. PMID:
41298504; PMCID: PMC12658218.
38: Bozkurt S, Fereydooni S, Kar I, Chalmers CD, Leslie SL, Pathak R, Walling
AM, Lindvall C, Lorenz K, Parikh R, Quest T, Giannitrapani K, Kavalieratos D. AI
in Palliative Care: A Scoping Review of Foundational Gaps and Future Directions
for Responsible Innovation. J Pain Symptom Manage. 2025 Dec;70(6):e394-e418.
doi: 10.1016/j.jpainsymman.2025.08.009. Epub 2025 Aug 21. PMID: 40849027.